Product Name: Mouse Anti-Human PRELP |
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Product Number: PDZMM122 |
Clonality: Monoclonal |
Conjugation: Unconjugated |
Host Species: Mouse |
Target Species: Human, Horse, Rat, Dog, Bovine |
Mouse Anti-Human PRELP
- Background
- Product Details
- Storage & Handling
- Applications
PRELP (Prolargin) is a leucine-rich repeat protein present in the extracellular matrix of connective tissues. It plays an important role in anchoring basement membranes to the underlying connective tissue and binding type I and II collagen to these membranes. PRELP’s involvement in the pathology of Hutchinson-Gilford Progeria Syndrome (HGP) has been suggested due to its inability to bind collagen in basement membranes and cartilage in the syndrome.
- Host Species: Mouse
- Target Species: Human
- Conjugation: Unconjugated
- Clonality: Monoclonal
- Isotype: IgM
Purification
This antibody is purified via immunoaffinity chromatography, using an immunogen peptide derived from the human PRELP protein, coupled to Sepharose 4B.
- Form: Liquid
- Storage Instructions: Store at -20°C upon receipt. Avoid repeated freeze-thaw cycles. The product is stable for several weeks at 4°C as an undiluted liquid.
- Storage Buffer: Phosphate Buffered Saline (PBS, pH 7.4), with stabilizers and ≤0.09% sodium azide.
For extended storage, aliquot and store at -20°C or below. Centrifuge if product is not completely clear after standing at room temperature.
Terms & Conditions
This product is guaranteed only when purchased directly from PADZA or its authorized distributors.
This antibody is suitable for a range of research applications:
- Western Blotting (WB)
- Immunohistochemistry (IHC-P, IHC-Frozen)
- Dot Blot
- Immunomicroscopy
- Immunofluorescence (IF)
- Flow Cytometry (FCM)
Recommended starting dilutions:
- Western Blotting: 3-5 µg/ml
- IHC (Paraffin/Frozen): 5-10 µg/ml
- Immunofluorescence: 5-10 µg/ml
- Flow Cytometry: 5-10 µg/ml
Note: Optimal dilutions should be determined by the end-user based on experimental conditions.
Overview
The Mouse Anti-Human PRELP antibody is designed to target Proline/Arginine-rich End Leucine-rich Repeat Protein (PRELP), a protein encoded by the PRELP gene. This protein plays a crucial role in the extracellular matrix of connective tissues, particularly in anchoring basement membranes to underlying connective tissues. PRELP binds to type I collagen and perlecan, playing a potential role in diseases like Hutchinson-Gilford Progeria Syndrome (HGP).
- Published Studies: We will update this section with studies where this antibody was successfully used. (“This antibody was featured in Journal XYZ, 2023, in studies on targeted immunotherapy.”)
References
This product was originally developed at the Avicenna Research Institute, Tehran, Iran, and transferred to PADZACompany as per contract 98/15/191 dated 98/01/10.
(You can view the article referenced in the NCBI: PMC4137948)
- Case Studies: Brief summaries of key research projects or notable outcomes demonstrating the product’s effectiveness.
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Publications & Research
Ordering Information
Sizes and Packaging Options: Various sizes (50 µL, 100 µL) and larger quantities are available.
Sizes | Ordering Code | Packaging | Availability |
50 µL | PDZMM101-50 | Standard vial | Order Now |
100 µL | PDZMM101-100 | Standard vial | Order Now |
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PADZA ensures product performance when purchased directly from PADZA or authorized distributors. Contact our scientific support team for any technical issues.
📩 Contact our Scientific Support Team for application-specific queries or troubleshooting.
Terms & Conditions: This product is guaranteed only when purchased directly from PADZA or its authorized distributors.
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