Product Name: Mouse Anti-Human Her2 |
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Product Number: PDZMM117 |
Clonality: Monoclonal |
Conjugation: Unconjugated |
Host Species: Mouse |
Target Species: Human |
Mouse Anti-Human Her2
HER2 (ERBB2) is a receptor tyrosine kinase, encoded by the ERBB2 gene in humans. It is part of the HER family, which includes other growth factor receptors. Amplification or over-expression of HER2 is known to drive the development and progression of certain aggressive forms of breast cancer, making it a critical target for cancer therapies. HER2 is also called HER2/neu and is a major biomarker in breast cancer, present in around 30% of cases. HER2-targeted therapies, such as trastuzumab (Herceptin), have significantly improved outcomes for breast cancer patients with this over-expression.
Properties
- Form: Liquid
- Storage instructions: Shipped at 4 °C. Store at -20 °C. Avoid freeze/thaw cycle. Please see notes section.
- Storage buffer: Phosphate buffered saline pH 7.4, contains stabilizer and ≤0.09% sodium azide.
- Purity: Immunogen affinity or SpG purified
- Purification notes: This product was prepared by immunoaffinity chromatography using immunogen peptide coupled to Sepharose 4B.
- Clonality: Monoclonal
- Isotype: IgG
- Conjugation: Unconjugated
Immunogen: A KLH-conjugated synthetic peptide derived from human ERBB2 (Her2) protein was used for immunization.
- Host species: Mouse
- Target species: Human
- Suitable for: Dot blot, ICC, IHC-Fr, IHC-P, WB, ELISA, Immunomicroscopy
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 μg/ml BSA, and 50% glycerol. Store at –20°C. After receiving, aliquot the antibody and store at –20°C.
General notes
For extended storage, aliquot contents and freeze at -20 °C or below. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4 °C as an undiluted liquid. Dilute only prior to immediate use.
Customer feedback indicates the antibody worked well in their applications. If the antibody does not yield the expected results, please contact our scientific support team for assistance.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end-user.
Recommended Dilution |
Western Blotting: 3-5 µg/ml
Immunohistochemistry (Paraffin): 5-10 µg/ml
Immunohistochemistry (Frozen): 5-10 µg/ml
Immunofluorescence: 5-10 µg/ml
Flow Cytometry: 5-10 µg/ml
Overview
This monoclonal antibody is specific for HER2 (human epidermal growth factor receptor 2), a receptor tyrosine kinase that plays a crucial role in the development and progression of certain aggressive breast cancers. HER2 is part of the HER/EGFR/ERBB family and is amplified or over-expressed in approximately 30% of breast cancer cases. It has become a significant biomarker and therapeutic target for breast cancer treatment. This antibody is widely used for research related to cancer biology, especially in studies focused on breast cancer and HER2-targeted therapies.
- Published Studies: We will update this section with studies where this antibody was successfully used. (“This antibody was featured in Journal XYZ, 2023, in studies on targeted immunotherapy.”)
References
Note: This product has originally been developed at Avicenna Research Institute, Tehran, IRAN and assigned to PADZA Company according to contract 98/15/191 dated 98/01/10.
(You can view the article referenced in the NCBI: PMC4137948)
- Case Studies: Brief summaries of key research projects or notable outcomes demonstrating the product’s effectiveness.
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Publications & Research
Ordering Information
Sizes and Packaging Options: Various sizes (50 µL, 100 µL) and larger quantities are available.
Sizes | Ordering Code | Packaging | Availability |
50 µL | PDZMM101-50 | Standard vial | Order Now |
100 µL | PDZMM101-100 | Standard vial | Order Now |
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PADZA ensures product performance when purchased directly from PADZA or authorized distributors. Contact our scientific support team for any technical issues.
📩 Contact our Scientific Support Team for application-specific queries or troubleshooting.
Terms & Conditions: This product is guaranteed only when purchased directly from PADZA or its authorized distributors.
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